Transient Receptor Potential Melastatin 6 Knockout Mice Are Lethal whereas Heterozygous Deletion Results in Mild Hypomagnesemia
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منابع مشابه
Transient receptor potential melastatin 6 knockout mice are lethal whereas heterozygous deletion results in mild hypomagnesemia.
BACKGROUND Hypomagnesemia with secondary hypocalcemia is due to disturbed renal and intestinal magnesium (Mg(2+)) (re)absorption. The underlying defect is a mutation in the transient receptor potential melastatin type 6 (TRPM6), a Mg(2+)-permeable ion channel expressed in the kidney and intestine. Our aim was to characterize homozygous (-/-) and heterozygous (+/-) TRPM6 knockout mice with respe...
متن کاملTransient Receptor Potential Melastatin 6 Knockout Mice Are Lethal whereas Heterozygous Deletion Results in Mild Hypomagnesemia
Background: Hypomagnesemia with secondary hypocalcemia is due to disturbed renal and intestinal magnesium (Mg 2+ ) (re)absorption. The underlying defect is a mutation in the transient receptor potential melastatin type 6 (TRPM6), a Mg 2+ -permeable ion channel expressed in the kidney and intestine. Our aim was to characterize homozygous (–/–) and heterozygous (+/–) TRPM6 knockout mice with resp...
متن کاملTransient Receptor Potential Melastatin 6 Knockout Mice Are Lethal whereas Heterozygous Deletion Results in Mild Hypomagnesemia
Background: Hypomagnesemia with secondary hypocalcemia is due to disturbed renal and intestinal magnesium (Mg 2+ ) (re)absorption. The underlying defect is a mutation in the transient receptor potential melastatin type 6 (TRPM6), a Mg 2+ -permeable ion channel expressed in the kidney and intestine. Our aim was to characterize homozygous (–/–) and heterozygous (+/–) TRPM6 knockout mice with resp...
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ژورنال
عنوان ژورنال: Nephron Physiology
سال: 2011
ISSN: 1660-2137,1660-2137
DOI: 10.1159/000320580